TrastuRel Trastuzumab 150mg & 440mg

ADDITIONAL INFORMATION

Strengths available : 150mg & 440mg

Storage : Store at temperature between 2°C – 8°C.

Dosage :

Precautionary Measures :

• Do not administer as an intravenous push or bolus.
• Do not mix Trasturel with other drugs.
• Do not substitute Trasturel (Trasturel) for or with ado-Trasturel emtansine.

Recommended Doses and Schedules:

Adjuvant Treatment, Breast Cancer: Administer according to one of the following doses and schedules for a total of 52 weeks of Trasturel therapy:

During and following paclitaxel, docetaxel, or docetaxel/carboplatin:

Initial dose of 4 mg/kg as an intravenous infusion over 90 minutes then at 2 mg/kg as an intravenous infusion over 30 minutes weekly during chemotherapy for the first 12 weeks (paclitaxel or docetaxel) or 18 weeks (docetaxel/carboplatin).

One week following the last weekly dose of Trasturel, administer Trasturel at 6 mg/kg as an intravenous infusion over 30–90 minutes every three weeks.

As a single agent within three weeks following completion of multi-modality, anthracycline-based chemotherapy regimens:

• Initial dose at 8 mg/kg as an intravenous infusion over 90 minutes
• Subsequent doses at 6 mg/kg as an intravenous infusion over 30–90 minutes every three weeks.
• Extending adjuvant treatment beyond one year is not recommended.

Metastatic Treatment, Breast Cancer: Administer Trasturel, alone or in combination with paclitaxel, at an initial dose of 4 mg/kg as a 90-minute intravenous infusion followed by subsequent once weekly doses of 2 mg/kg as 30-minute intravenous infusions until disease progression.

Metastatic Gastric Cancer: Administer Trasturel at an initial dose of 8 mg/kg as a 90-minute intravenous infusion followed by subsequent doses of 6 mg/kg as an intravenous infusion over 30–90 minutes every three weeks until disease progression.