Pamidronate Disodium IV Infusion BP 30 mg & 60 mg is used in treatment of moderate to severe hypercalcemia associated with malignancy with or without bone metastases; treatment of moderate to severe Paget disease of bone; treatment of osteolytic bone lesions of multiple myeloma and bone metastases of breast cancer in conjunction with standard chemotherapy.
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Moderate to Severe Hypercalcemia of Malignancy Adults
IV For moderate, give 60 to 90 mg as an initial single-dose infusion over 2 to 24 h. For severe, give 90 mg as an initial single-dose infusion over 2 to 24 h. For retreatment, same as initial therapy, at least 7 days after initial dose.
Paget Disease Adults
IV 30 mg/day as a 4-h infusion on 3 consecutive days for a total dose of 90 mg. For retreatment, same as initial therapy, when clinically indicated.
Osteolytic Bone Metastases of Breast Cancer Adults
IV 90 mg as a 2-h infusion every 3 to 4 wk.
Osteolytic Bone Lesions of Multiple Myeloma Adults