Lyophilized Oxaliplatin Injection 50 & 100mg is used in adjuvant treatment of stage III colon cancer in combination with infusional 5-fluorouracil/leucovorin in patients who have undergone complete resection of the primary tumor and in combination with infusional 5-fluorouracil/leucovorin for the treatment of advanced colorectal cancer.The cytotoxic effect of oxaliplatin has been correlated with formation of inter- and intrastrand DNA crosslinks that inhibit DNA replication and transcription. Cytotoxicity is cell-cycle nonspecific.
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Oxaliplatin should not be administered to patients with a history of known allergy to Oxaliplatin or other platinum compounds.