Asparaginase is an enzyme that catalyzes the hydrolysis of asparagine to aspartic acid. It is used for the treatment of acute lymphoblastic leukemia (ALL) and is also used in some mast cell tumor protocols ,Unlike other chemotherapy agents, it can be given as an intramuscular, subcutaneous, or intravenous injection without fear of tissue irritation. L- Asparaginase Injection 5000 & 10,000 KU is used in treatment of Acute leukaemia. Malignant lymphoma and Acute lymphoblastic leukaemia.
There are many generic manufacturers in India who manufacture L- Asparaginase Injection 5000 & 10,000 KU including Biochem Pharmaceutical etc.
3s corporation is Supplier,Exporter ,Wholesaler for L- Asparaginase Injection 5000 & 10,000 KU in India.
Before treatment is started a test dose of 1 to 10 KU of L-Asparaginase in 0.1 ml of distilled water should be injected subcutaneously and the injection site observed for several hours of evidence of primary hypersensitivity.
Side Effects: Nausea, stomach upset, skin rash, acute toxicity.
The main side effect is an allergic or hypersensitivity reaction; anaphylaxis is a possibility.Asparaginase has also been associated with pancreatitis. Additionally, it can also be associated with a coagulopathy as it decreases protein synthesis, including synthesis of coagulation factors (eg progressive isolated decrease of fibrinogen) and anticoagulant factor (generally antithrombin III; sometimes protein C & S as well), leading to bleeding or thrombotic events such as stroke.