DigiFab 40mg (DIGOXIN IMMUNE FAB (OVINE)) is used as an antidote to treat a life-threatening or potentially life-threatening digoxin toxicity or overdose of digoxin or digitoxin and not used to treat a mild digitalis overdose.
Manufacturer : GlaxoSmithKline
Strengths available : 40mg
Storage : Store at temperature between 2°C – 8°C
Acute ingestion of unknown amounts of digoxin and toxicity in the absence of a serum digitalis concentration or estimated ingestion amount : Administer 20 vials of DigiFab. Monitor for volume overload in small (< 20 Kg) children. Start with 10 vials followed by an additional 10 vials, if needed, to avoid a febrile reaction.
Chronic digoxin toxicity in the absence of a serum digitalis concentration : Administer 6 vials of DigiFab in Adults and Children ≥ 20 Kg.
Acute ingestion of known amounts of digoxin : Dose (in vials) = Amount of digoxin ingested (in mg) 0.5 mg/vial
Chronic digoxin toxicity and known serum digitalis concentration : Dose (in vials) = (Serum digoxin ng/mL)(weight in kg) 100
Common side effects are signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, throat, Signs of low potassium levels, Very bad dizziness, Cough, A fast heartbeat.