Bortezomib for Injection is an antineoplastic agent available for intravenous injection or subcutaneous use. It is used in the treatment of Multiple Myeloma and Mantle Cell Lymphoma . Each vial contains bortezomib as a sterile lyophilized powder and inactive ingredient.
Bortezomib is a modified dipeptidyl boronic acid. The product is provided as a mannitol boronic ester which, in reconstituted form, consists of the mannitol ester in equilibrium with its hydrolysis product, the monomeric boronic acid. The drug substance exists in its cyclic anhydride form as a trimeric boroxine. It comes in two dosage i.e. 2 mg & 3.5 mg. It has to be stored at 2-8 degree celsius and comes in powder form with solvent.
It is manufactured by many Indian manufacturers like Jannsen, Celon Labs, Natco Pharma etc. 3s corporation is supplier,Exporter for Bortezomib for Injection in India. It is popularly known as Velcade in Europe and America.
Reconstitute with 3.5 mL of 0.9% Sodium Chloride resulting in a final concentration of 1 mg/mL of bortezomib. The reconstituted product should be a clear and colorless solution.
Reconstituted solution should be administered within 8 hours of preparation.
swelling of your face, lips, tongue, or throat.
Bortezomib may cause a serious viral infection of the brain that can lead to disability or death