Atgam ( Lymphocyte immunoglobulin antithymocyte) injection from Pfizer is used for ;
1. Prevention and treatment of acute renal allograft rejection
2. Prevention of graft-vs-host disease (GVHD) in bone marrow transplant (BMT) patients.
3. Treatment of aplastic anemia in patients not suitable for BMT.
1.Fever (most pts), chills, hypotension, hypertension, dyspnea, chest pain, tachycardia, and edema.
2.Leukopenia (>10%) and thrombocytopenia (>10%); anemia (<1%)
4.Skin reactions (rash; pruritus, etc): most pts.
5.Nausea, diarrhea, stomititis, GI bleed.
6.Myalgia; back pain (>1%); seizures (<1%)