Aclasta is the Novartis brand name of zoledronic acid or zoledronate, which is a bisphosphonate. Aclasta is used to treat osteoporosis in postmenopausal women and in men. Aclasta’s purpose is to prevent additional fractures in men or women who have recently had a hip fracture. Aclasta could also be used to treat and prevent osteoporosis in men and women caused by treatment with steroid medicines such as prednisone. Aclasta is also used to treat Paget’s disease of bone.
For Paget’s disease and for the prevention of osteoporosis in postmenopausal women, the recommended dose of zoledronic acid is 5 mg given as a one-time intravenous (into a vein) infusion.
For treatment of osteoporosis in men, and for treatment and prevention of osteoporosis caused by steroid medications, the recommended dose is 5 mg given as an intravenous (into a vein) infusion once a year. Infusions are given by a doctor or nurse over at least 15 minutes.
It is recommended that people taking this medication take calcium and vitamin D supplements to prevent low blood calcium levels. Your doctor will recommend a dose of these supplements based on your needs.
On the day of the infusion, it is important to drink at least 500 mL (2 cups) of fluids before and after the treatment.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are receiving the medication without consulting your doctor.
It is important to receive this medication exactly as recommended by your doctor. If you miss an appointment to receive zoledronic acid, contact your doctor as soon as possible to reschedule your appointment.
This medication is stored at room temperature.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
bone, muscle, or joint pain
fever and chills
flu-like symptoms (e.g., fever, chills, bone pain, or muscle and joint pain)
Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
eye pain, redness, or inflammation
shortness of breath
signs of low blood calcium levels (e.g., muscle spasms, tingling or numbness of the fingers and mouth, twitching, or memory loss)
Stop taking the medication and seek immediate medical attention if any of the following occur:
signs of a severe allergic reaction (e.g., hives; difficulty breathing; swelling of the mouth, lips, tongue, or throat)