Abacavir sulphate is an anti-HIV medicine that is used in the treatment of infection with human immunodeficiency virus ( HIV). It is used in combination with other anti-HIV medicines.HIV weakens the body’s immune system and reduces the body’s ability to fight infections. Anti-HIV medicines do not kill thevirus but they slow down or stop the HIV virus from making copies of itself. This allows the body’s immune system to keep working and gives the body a chance to fight other infections. Anti-HIV medicines do not cure HIV infections or prevent you from getting other infections.For HIV therapy to be effective and to reduce the chances of developing resistance to your medicine, it is important you take the full daily dose and take your medicines exactly as prescribed by your doctor.
Adults Dose : 600 mg daily, administered as either 300 mg twice daily or 600 mg once daily.
Pediatric Patients Aged 3 Months and Older: Dose should be calculated on body weight (kg) and should not exceed 300 mg twice daily.
Patients With Hepatic Impairment: Mild hepatic impairment – 200 mg twice daily; moderate/severe hepatic impairment – contraindicated.
General Common: Fever, lethargy, malaise Also reported: edema, lymphadenopathy, hypotension, conjunctivitis, anaphylaxis
Skin Common: rash
Gastrointestinal Common: nausea, vomiting, diarrhea, abdominal pain, elevated liver enzymes Also reported: mouth ulceration, hepatitis, liver failure
Respiratory Common: dyspnea, cough Also reported: sore throat, adult respiratory distress syndrome, respiratory failure
Neurological/Psychiatric Common: headache
paresthesias Musculoskeletal Common: myalgia , myolysis (rare), arthralgia, elevated creatine phosphokinase (CPK) Other Also reported: leukopenia, elevated creatinine levels, renal failure Rash and gastrointestinal manifestations (70% vs 54% respectively).