Description : Rocuronium is a prescribed drug used to give before general anesthesia to relax the skeletal muscle before surgery. Rocuronium relaxes the muscles by blocking the impulses from the nerves. To buy ‘Rocuronium’ or to know its price contact India’s leading wholesaler and exporter 3S Corporation.
Side Effect : Some common side effects of Rocuronium may include Skin rash, Increased saliva production, Increased heart rate, Injection site reactions (pain, swelling, redness), High blood pressure.
Dosage : Recommended Adult Dose For Anesthesia :
-Initial dose: 0.6 mg/kg IV
-An 80% block or greater is attained in a time of 1 (0.4 to 6) minute(s) and most patients have intubation completed within 2 minutes.
-Maximum blockade is achieved in most patients in less than 3 minutes.
-This dose may be expected to provide 31 (15 to 85) minutes of relaxation under opioid/nitrous oxide/oxygen anesthesia (under halothane, isoflurane, and enflurane anesthesia, some extension of the period of relaxation should be expected).
-Maintenance doses of 0.1, 0.15, and 0.2 mg/kg administered at 25% recovery of control T1 (defined as 3 twitches of train-of-four), provide a median of 12 (2 to 31), 17 (6 to 50), and 24 (7 to 69) minutes of duration under opioid/nitrous oxide/oxygen anesthesia.
-Dosing should be guided based on the duration following initial dose or prior maintenance dose and not administered until recovery of neuromuscular function is evident.
-An insignificant cumulation of effect with repetitive maintenance dosing has been observed.
-An initial rate of 10 to 12 mcg/kg/min should be initiated only after early evidence of spontaneous recovery from an intubating dose.
Recommended Dose For Infants And Children :
TRACHEAL INTUBATION: 0.45 to 0.6 mg/kg IV depending on anesthetic technique and the age of the patient should produce good intubating conditions within 75 seconds when used with sevoflurane; when halothane is used, a 0.6 mg/kg dose resulted in excellent to good intubating conditions within 60 seconds.
-The time to maximum block for an intubating dose is shortest in infants (28 days up to 3 months) and longest in neonates (birth to less than 28 days). The duration of relaxation following an intubating dose is shortest in children (greater than 2 years up to 11 years) and longest in infants.
-When sevoflurane is used for induction and isoflurane/nitrous oxide for maintenance of general anesthesia, maintenance dosing can be administered as bolus doses of 0.15 mg/kg at reappearance of T3 in all pediatric age groups.
-Maintenance dosing can also be administered at the reappearance of T2 at a rate of 7 to 10 mcg/kg/min, with the lowest dose requirement for neonates (birth to less than 28 days) and the highest dose requirement for children (greater than 2 years up to 11 years).
-When halothane is used for general anesthesia, patients ranging from 3 months old through adolescence can be administered doses of 0.075 to 0.125 mg/kg upon return of T1 to 0.25% to provide clinical relaxation for 7 to 10 minutes; alternatively, a continuous infusion initiated at a rate of 12 mcg/kg/min upon return of T1 to 10% (one twitch present in train-of-four) may also be used to maintain neuromuscular blockade in pediatric patients.
Storage : Store in a refrigerator (2°C – 8°C). Do not freeze.
FDA Approved : August 13, 2019
December 11, 2020