Description : Atracurium injection is a prescribed drug used as general anesthesia to calm muscles during surgery and to provide skeletal muscle relaxation during mechanical ventilation. Atracurium should be administered intravenously because intramuscular administration of Atracurium may cause tissue irritation and there are no clinical data to support this route of administration. To buy ‘Atracurium Injection’ or to know its price contact India’s leading wholesaler and exporter 3S Corporation.
Side Effect : Some common side effects of Atracurium may include Skin flush, Itching, Hives, Erythema and wheezing.
Dosage : To avoid distress in patient, Atracurium should not be administered before unconsciousness has been induced. Atracurium should not be mixed in the same syringe or administered simultaneously through the same needle , with alkaline solutions (e.g., barbiturate solutions).
Bolus Doses for intubation and Maintenance of Neuromuscular Block –
Adults – An atracurium dose of 0.4 to 0.5 mg/kg , given as an intravenous bolus injection, is the recommended initial dose for most patients. Atracurium doses of 0.08 to 0.10 mg/kg are recommended for maintenance of neuromuscular block during prolonged surgical procedures. The first maintenance dose will generally be required 20 to 45 minutes after the initial Atracurium injection, but the need for maintenance doses should be determined by clinical criteria.
Pediatric Patient– No Atracurium dosage adjustments are required for pediatric patients two years of age or older. An Atracurium dose of 0.3 to 0.4 mg/kg is recommended as the initial dose for infants (1 month to 2 years of age) under halothane Anesthesia. Maintenance doses may be required with slightly greater frequency in infants and children than in adults.
Special Considerations – An initial Atracurium dose of 0.3 to 0.4 mg/kg, given slowly or in divided doses over one minute, is recommended for adults, children, or infants with significant cardiovascular disease and for adults, children, or infants with any history (e.g., severe ana-phylactoid reactions or asthma) suggesting a greater risk of histamine release.
Use by Continuous Infusion-
Infusion in the Operating Room (OR) – After administration of a recommended initial bolus dose of Atracurium injection (0.3 to 0.5 mg/kg), a diluted solution of Atracurium can be administered by continuous infusion to adults and pediatric patients aged 2 or more years for maintenance of neuromuscular block during extended surgical procedures. Infusion of Atracurium should be individualized for each patient. The rate of administration should be adjusted according to the patient’s response as determined by peripheral nerve stimulation. Accurate dosing is best achieved using a precision infusion device. Infusion of Atracurium should be initiated only after early evidence of spontaneous recovery from the bolus dose. An initial infusion rate of 9 to 10 mcg/kg/min may be required to rapidly counteract the spontaneous recovery of neuromuscular function. Thereafter, a rate of 5 to 9 mcg/kg/min should be adequate to maintain continuous neuromuscular block in the range of 89% to 99% in most pediatric and adult patients under balanced anesthesia. Occasional patients may require infusion rates as low as 2 mcg/kg/min or as high as 15 mcg/kg/min.
Infusion in the Intensive Care Unit (ICU) – The principles for infusion of Atracurium in the OR are also applicable to use in the ICU An infusion rate of 11 to 13 mcg/kg/min should provide adequate neuromuscular block in adult patients in an ICU. Limited information suggests that infusion rates required for pediatric patients in the ICU may be higher than in adult patients.
Storage : Store in a refrigerator (2 – 8°C). Do not freeze.
FDA Approved : n/a
December 10, 2020