Glivec 100 mg

Description

Glivec (imatinib) is a prescription drug manufactured by Novartis Pharma. It is used in the treatment of various types of cancers including Philadelphia chromosome-positive (Ph+) & chronic myelogenous leukemia (CML). It is available in tablet form in two dosages 100 mg & 400 mg. There are also a lot of generic manufacturers in India who offer cheaper generic versions of Glivev (Imatinib) in India.

Uses:

  • Newly diagnosed adult and pediatric patients with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in the chronic phase
  • Patients with Ph+ CML in blast crisis (BC), accelerated phase (AP), or in the chronic phase (CP) after failure of interferon-alpha therapy
  • Adult patients with relapsed or refractory Ph+ acute lymphoblastic leukemia (Ph+ ALL)
  • Pediatric patients with newly diagnosed Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) in combination with chemotherapy
  • Adult patients with myelodysplastic/myeloproliferative diseases (MDS/MPD) associated with PDGFR (platelet-derived growth factor receptor) gene rearrangements
  • Adult patients with aggressive systemic mastocytosis (ASM) without the D816V c-KIT mutation or with c-KIT mutational status unknown
  • Adult patients with hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukemia (CEL) who have the FIP1L1-PDGFRα fusion kinase and for patients with HES and/or CEL who are FIP1L1-PDGFRα fusion kinase negative or unknown
  • Adult patients with unresectable, recurrent, and/or metastatic dermatofibrosarcoma protuberans (DFSP)
  • Patients with KIT(CD117)-positive gastrointestinal stromal tumors (GISTs) that are cancerous, cannot be surgically removed, and/or have spread to other parts of the body
  • Adult patients after surgery who have had their KIT (CD117)-positive GISTs completely removed

Additional Information

Side Effects

After the approval of GLEEVEC, the following serious side effects have been reported in patients:

  • Severe fluid retention (holding water) and swelling
  • Cytopenias (reduction of certain elements in blood circulation)
  • Severe congestive heart failure (impaired ability of the heart to pump blood) and left ventricular dysfunction (impaired functioning of the left side of the heart)
  • Severe liver problems (hepatotoxicity)
  • Hemorrhage (abnormal bleeding)
  • GI perforation (holes in the stomach or intestine)
  • Hypereosinophilic (a condition with increased eosinophils, which are a type of white blood cell) heart disease
  • Skin reactions (such as fluid-filled blisters)
  • Hypothyroidism (reduction in thyroid hormones)
  • Potential toxicities from long-term use, specifically liver, kidney, and/or heart toxicities
  • Potential harm to an unborn child
  • Growth retardation (slowing of growth)
  • Tumor lysis syndrome (electrolyte disturbance)
  • Dizziness, blurred vision, and somnolence
  • Fluid retention (holding water)
  • Muscle cramps, pain, or bone pain
  • Abdominal pain
  • Anorexia (loss of appetite)
  • Vomiting
  • Diarrhea
  • Decreased hemoglobin (decrease in blood cells which carry oxygen)
  • Hemorrhage (abnormal bleeding)
  • Nausea
  • Fatigue
  • Rash

Pack Size