3S Corporation is one of India’s leading stockist, exporter & wholesaler for Anti-cancer drug & Oncology medicines. We even supply & export Sex Enhancement Drugs, Cardiac & Anti Diabetic Medicines. We are a registered wholesaler & exporter for pharmaceutical products licensed by our FDA and Drug Controller in India. Our license number are 20-B/MZ6-23015 & 21-B/ MZ6-23016.
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EVERTOR™ (Everolimus) is a prescription drug manufactured by Biocon India, indicated for the treatment of patients with advanced renal cell carcinoma (RCC) after failure of treatment with Sunitinib or Sorafenib. It is also popular as the generic version of Afinitor manufactured by Novartis. Its pack size is of 10 tabs. Available in 5 & 10 mg tablet
How does it work?
Evertor tablets contain the active ingredient everolimus, which is a type of medicine known as a protein kinase inhibitor. It works by interfering with the pathways that signal certain cancer cells to grow.
The way that cells in the body work and grow is regulated by various enzymes called protein kinases. These enzymes can be found in certain receptors on the surface of cells that are involved in the growth and spread of cancer cells.
In cancerous cells, the kinases make the cells grow and multiply abnormally. They also stimulate nearby blood vessels to grow into the tumour. The new blood vessels allow the cancer cells to grow and multiply by supplying them with oxygen and nutrients. They also allow the cancerous cells to spread into other areas of the body through the blood circulation.
Everolimus works by attaching to a certain protein inside the cancer cells and blocking the action of a protein kinase called mammalian target of rapamycin (mTOR). This stops the signals that tell the cancer cells to grow and multiply. It also stops blood vessels growing into the tumour. This reduces the tumour’s blood supply and with it, its supply of oxygen and nutrients. Both these effects stop the tumour from growing.
What is it used for?
This drug is used to treat kidney cancer, breast cancer, and neuroendocrine tumor. It may also be used for other conditions, and it is being studied for use in treating a number of other cancers.
How do I take it?
Evertor tablets should be taken once a day at the same time each day. Swallow the tablets whole with a glass of water; do not break, crush or chew them.
Evertor tablets can be taken either with or without food. However, you should be consistent in the way you take them – either always take your tablet with food, or always take it without food. This helps to maintain consistent effective levels of the medicine in your blood.
You should avoid drinking grapefruit juice or eating grapefruit while taking this medicine, as it may increase the level of this medicine in your blood and hence increase the risk of side effects.
If you forget to take a dose at your normal time, just skip that dose and take your next dose as usual. Do not take a double dose to make up for a missed dose
Mouth ulcers and inflammation of the lining of the mouth are common side effects experienced by people taking this medicine. It is important to speak to your doctor or pharmacist before treating any mouth ulcers or soreness in your mouth. Mouthwashes containing alcohol or peroxide should be avoided as they can make the problem worse.
This medicine can increase your risk of getting infections, including pneumonia or other bacterial infections, invasive fungal infections, such as aspergillosis or candidiasis (thrush), and viral infections including reactivation of hepatitis B. You should tell your doctor immediately if you notice any signs of infection while you are taking this medicine, for example, a high temperature (fever), sore throat, mouth ulcers or swollen glands. If you get an infection you may need to stop taking this medicine while it is treated.
This medicine can sometimes cause lung inflammation. You should tell your doctor if you experience any new or worsening shortness of breath, difficulty breathing or cough while taking this medicine, so this can be investigated.
This medicine can decrease the number of blood cells in your blood. A low white blood cell count can increase your susceptibility to infections; a low red blood cell count causes anaemia and a low platelet count can cause problems with blood clotting and increase the risk of bleeding. For this reason, you will need regular blood tests to monitor your blood cells during treatment with this medicine. Tell your doctor immediately if you experience any of the following symptoms during your treatment, as they may indicate problems with your blood cells: unexplained bruising or bleeding, purple spots, sore mouth or throat, mouth ulcers, high temperature (fever) or other signs of infection, or suddenly feeling tired, breathless, or generally unwell.
You should also have regular blood tests to monitor your liver and kidney function and your blood sugar and cholesterol levels while you are having treatment with this medicine.
This medicine can slow wound healing. For this reason, you may need to stop taking this medicine before any major surgical procedures or operation. Follow your doctor’s instructions.
This medicine could be harmful to a developing baby. Women who could get pregnant must use a reliable method of contraception to avoid getting pregnant while taking this medicine. Seek further medical advice from your doctor. Tell your doctor immediately if you think you could be pregnant during treatment.
The ability of men to father a child may be affected by treatment with this medicine. It is important to discuss fertility with your doctor before starting treatment.
Use with caution in
People with an infection (infections should normally be treated before this medicine is started).
People with a history of hepatitis B infection.
People with liver disease.
People with decreased kidney function.
People with raised levels of cholesterol in their blood.
People who have recently had surgery.
Not to be used in
Rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption (Evertor tablets contain lactose).
This medicine is not recommended for people with severely decreased liver function, as it has not been studied in people with severe liver problems.
This medicine is not recommended for children and adolescents under 18 years of age, as its safety and effectiveness have not been studied in this age group.
This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
This medicine could be harmful to a developing baby. It should not be used during pregnancy. Women who could get pregnant must use a reliable method of contraception to avoid getting pregnant while taking this medicine. Seek further medical advice from your doctor on which types of contraception are recommended. You should continue to use contraception to prevent pregnancy for at least 8 weeks after you have stopped taking this medicine. Tell your doctor straight away if you think you could be pregnant while taking this medicine.
It is not known if this medicine passes into breast milk. Mothers who need to take this medicine should not breastfeed, because if the medicine does pass into the breast milk it could be harmful to a nursing infant. Seek medical advice from your doctor.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Decrease in the number of red blood cells or platelets in the blood (anaemia or thrombocytopenia – see warning section above).
Infections (see warning section above).
Inflammation of the lining of the mouth (stomatitis) or mouth ulcers (see warning section above).
Feeling weak or tired.
Change in taste.
Loss of appetite.
Disturbances of the gut such as diarrhoea, nausea or vomiting.
Inflammation of the lungs (pneumonitis – see warning section above).
Shortness of breath (dyspnoea).
Skin reactions such as dry skin, itching or rash.
Swollen ankles due to fluid retention.
Increased levels of fats called cholesterol and triglycerides in the blood.
Increased blood sugar levels (hyperglycemia).
Decreased numbers of white blood cells in the blood (see warning section above).
Difficulty sleeping (insomnia).
Inflammation of the eyes (conjunctivitis).
Swelling of the eyelids.
Difficulty or pain when swallowing (dysphagia).
Indigestion or stomach ache.
Painful redness, swelling, blistering or ulceration of the palms and soles (hand-foot syndrome or palmar-plantar erythrodysesthesia).
Skin redness, peeling or inflammation.
Mild hair loss.
Increased blood pressure (hypertension).
Coughing up blood.
Blood clot in the lungs (pulmonary embolism).
Decreased levels of potassium, calcium or phosphate in the blood (hypokalaemia, hypophosphataemia or hypocalcaemia).
Slowed wound healing.
Loss of sense of taste.
Blood clot in a vein of the leg (deep vein thrombosis).
Swelling of the lips, throat and tongue (angioedema).
The side effects listed above may not include all of the side effects reported by the medicine’s manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
Disclaimer: The information provided above is general. It does not include all possible uses, actions, precautions, side effects, or interactions. It is not intended as medical advice, and should not be relied upon as a substitute for your doctor’s advice. Please consult your doctor before taking any action towards your medical condition.